Pure Encapsulations® SAMe (S-Adenosylmethionine), 60 vcaps
SKU:
SAM6
$68.10
$68.10
per item
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Pure Encapsulations® SAMe (S-Adenosylmethionine) is formulated to help maintain cognitive health, liver function, and joint comfort. SAMe also promotes healthy cell growth and positive mood. Order your bottle today!
Quality & Purity
Pure Encapsulations® manufactures a line of hypoallergenic, research-based dietary supplements that are designed to deliver predictable and desired results to help your body operate at its fullest potential. Pure Encapsulations® is committed to sourcing pure, premium ingredients to help you achieve optimal health. Products are nothing but pure. Dietary supplements are formulated with premium raw ingredients and are scientifically tested to ensure that each ingredient and final product meets quality standards. All Pure Encapsulations® products are free from wheat and gluten; eggs; peanuts; coatings and shellacs; GMOs; magnesium stearate; trans fats and hydrogenated oils; artificial colors, flavors, and sweeteners; and unnecessary binders, fillers, and preservatives. Pure Encapsulations® source premium raw materials from trusted industry leaders, including the finest suppliers from the United States, France, Japan, Switzerland, Germany, and Italy. All ingredients are tested for purity and potency by independent certified laboratories. Ingredient suppliers must meet rigorous testing and quality criteria to quality as a Pure Encapsulations® supplier.
This product is manufactured according to the cGMP Standards and Inspection. Tests before, during, and after processing guarantee uniform quality and purity. Quality manufacturing practices are essential to the integrity of professionally oriented natural health products. That is why our dispensary is independently registered by NSF® to meet cGMP requirements for the brands we carry. NSF International audits each of our facilities twice per year. Together, we offer industry-leading shipping times and reliability. Orders placed before 4:30 PM EST are processed and shipped the same day and will arrive at your door within days.
What is SAMe (S-Adenosylmethionine)?
Uses for SAMe (S-Adenosylmethionine)
Potential Side Effects or Precautions
Potential Drug Interactions
Pure Encapsulations® manufactures a line of hypoallergenic, research-based dietary supplements that are designed to deliver predictable and desired results to help your body operate at its fullest potential. Pure Encapsulations® is committed to sourcing pure, premium ingredients to help you achieve optimal health. Products are nothing but pure. Dietary supplements are formulated with premium raw ingredients and are scientifically tested to ensure that each ingredient and final product meets quality standards. All Pure Encapsulations® products are free from wheat and gluten; eggs; peanuts; coatings and shellacs; GMOs; magnesium stearate; trans fats and hydrogenated oils; artificial colors, flavors, and sweeteners; and unnecessary binders, fillers, and preservatives. Pure Encapsulations® source premium raw materials from trusted industry leaders, including the finest suppliers from the United States, France, Japan, Switzerland, Germany, and Italy. All ingredients are tested for purity and potency by independent certified laboratories. Ingredient suppliers must meet rigorous testing and quality criteria to quality as a Pure Encapsulations® supplier.
This product is manufactured according to the cGMP Standards and Inspection. Tests before, during, and after processing guarantee uniform quality and purity. Quality manufacturing practices are essential to the integrity of professionally oriented natural health products. That is why our dispensary is independently registered by NSF® to meet cGMP requirements for the brands we carry. NSF International audits each of our facilities twice per year. Together, we offer industry-leading shipping times and reliability. Orders placed before 4:30 PM EST are processed and shipped the same day and will arrive at your door within days.
What is SAMe (S-Adenosylmethionine)?
- SAMe (S-Adenosylmethionine) is a metabolite present in all living cells. It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids and proteins. Research indicates support for positive mood, cell membrane fluidity, neurotransmitter synthesis, glutathione production, joint comfort, and healthy cell growth.
Uses for SAMe (S-Adenosylmethionine)
- Cellular Function: SAMe functions as a donor of methyl groups in over 100 different reactions catalyzed by methyltransferase enzymes. Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function. Healthy methylation is vital for cellular health, hormone and neurotransmitter production, and energy metabolism. SAMe also functions as a precursor molecule for glutathione and promotes polyamine synthesis. Clinical trials indicate that SAMe administration enhances glutathione production in hepatic tissue and red blood cells. The polyamines spermidine and spermine maintain healthy cell growth and cytokine balance.
- Cognitive Health: Over 40 clinical studies indicate that SAMe promotes positive mood and cognitive function. In a metaanalysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood. While the exact mechanism for this benefit has not been determined, it is believed that SAMe supports neurotransmitter monoamine synthesis and function, including dopamine and serotonin, through SAMe-dependent methylation reactions. It also promotes healthy protein turnover to support healthy CNS function and maintains healthy phospholipid methylation to support phosphatidylcholine production, as well as cellular membrane integrity and fluidity.
- Joint Function: Multiple clinical trials indicate that SAMe supports joint comfort and flexibility. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. In another 16-week, randomized, double-blind, placebo-controlled trial involving 56 subjects, SAMe offered statistically significant support for joint comfort. It is believed that SAMe enhances joint comfort and function by supporting proteoglycan synthesis, and by helping to stabilize and protect the proteoglycans.
Potential Side Effects or Precautions
- Consult your healthcare provider before use if you are pregnant or nursing, taking antidepressant medication, or if you have bipolar disorder.
- In rare cases, SAMe has been associated with flatulence, nausea, vomiting, diarrhea, constipation, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness.
- Anxiety and tiredness have occurred in people with depression, and hypomania in people with bipolar disorder.
- Consult your physician for more information.
Potential Drug Interactions
- SAMe is contraindicated with anti-depressant medication, dextromethorphan, and meperidine (Demerol).
- Concurrent use might cause additive serotonergic effects and serotonin syndromelike effects.
- It is also contraindicated with Levodopa.
- Consult your physician for more information.
